4 edition of Animal models of obesity found in the catalog.
Animal models of obesity
|Statement||edited by Michael F. W. Festing.|
|Series||MRC Laboratory Animals Center symposium ; no. 1|
|Contributions||Festing, Michael F. W., Laboratory Animals Centre (M.R.C. Laboratories)|
|LC Classifications||RC628 .A54|
|The Physical Object|
|Pagination||x, 258 p. :|
|Number of Pages||258|
|LC Control Number||79013414|
The Genetics of Obesity - CRC Press Book nongenetic determinants of obesity and fat topography, and animal models and molecular biological technology used to delineate the genetic basis of human obesities. A major portion of the book is devoted to human genetic research and clinical observations encompassing adoption studies, twin studies. The diet-induced obesity model (DIO model) is an animal model used to study obesity using animals that have obesity caused by being fed high-fat or high-density diets. It is intended to mimic the most common cause of obesity in humans. Typically mice, rats, dogs, or non-human primates are used in these models.
An overview is provided which describes the animal models of obesity most commonly utilized in research. A standardized laboratory protocol for producing diet?]induced obesity (DIO) in both mouse and rat is provided as are protocols that describe how diet formulation can be modified to generate mouse models of human metabolic : Cambridge Core - Epidemiology Public Health and Medical Statistics - Models of Obesity - by Stanley J. UlijaszekCited by: 5.
Biology of Obesity: Lessons from Animal Models of Obesity Table 1 Different phenotypes of inbred mouse strains with diet- or genetically induced obesity (summary of references [ 50, 74, 75 ]). This volume comprises papers presented at a symposium organised by the Medical Research Council Laboratory Animals Centre held in London on February 16th and 17th, The problem of obesity becomes more acute as people become more affluent. Research on humans has obvious limitations and in this book the use of animal models for studying obesity is considered.
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Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease.
The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological. Animal models of obesity book is a review of animal models of obesity currently used in research.
We have focused upon more commonly utilized models since there are far too many newly created models to consider, especially those caused by selective molecular genetic approaches modifying one or more genes in specific populations of by: Animal models used in the discovery of novel ligands for the treatment of obesity The regulation of body weight is dependent upon the interaction between food intake and energy expenditure.
For example, if, over an extended period of time daily food intake increases with an insufficient increase in energy expenditure (the energy imbalance gap Cited by: Animal obesity can be classified based on their etiology; however, till now, no animal model of obesity can replicate models of the human condition, they have only provided clues into the causes.
Genre/Form: Conference papers and proceedings Congresses: Additional Physical Format: Online version: Animal models of obesity. New York: Oxford University Press, COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library Animal models of obesity book as they consider how to handle coronavirus.
Development of safe and potent therapeutics is required to combat the obesity and diabetes mellitus pandemic. Animal models remain indispensable for discovering, validating and optimizing novel Cited by: Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences.
Offering easily searchable advantages and disadvantages for each animal model and organized by disease. The focus of this overview is on the animal models of obesity most commonly utilized in research.
The models include monogenic models in the leptin pathway, polygenic diet‐dependent models, and, in particular for their historical perspective, surgical and chemical models of by: P arasuraman and E e W en: Animal model for obesity-An ov erview 10 Systematic Reviews in Pharmacy, Vol 6, Issue 1, Jan-Dec, fat.
9 MSG can be administered (4. Many animal models that are currently used in appetite and obesity research share at least some main features of human obesity and its comorbidities. Hence, even though no animal model replicates all aspects of “common” human obesity, animal models are imperative in studying the control of energy balance and reasons for its imbalance that Author: Thomas A.
Lutz. ISBN Digitally watermarked, DRM-free Included format: PDF ebooks can be used on all reading devices Immediate eBook download after purchase. Search within book. Front Matter.
Pages i-x. PDF. Normal variation in body fat and its inheritance. McCarthy. Pages The inheritance of obesity in animal models of obesity. Festing. Pages The characteristics of genetically obese mutants. David A. York. Pages The husbandry and maintenance of genetic models of. In animal models obesity is highly associated with reduced glucose tolerance: properties related to type 2 diabetes and obesity are discussed.
While the genetic basis remains unknown, caloric restriction does prevent obesity and associated diseases in animals: the lessons for prevention of.
Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences.
Animal Models of Genetic Obesity: Peripheral Tissue Changes (P.R. Johnson and F. Gregoire). Identification of Genes Underlying Polygenic Obesity in Animal Models (C.H.
Warden and J.S. Fisler). Genetics and Molecular Biology of Adipose Cell Characteristics (G. The prevalence of obesity has now reached such proportions that in many parts of the world it is one of the most dominant health problems.
Obesity leads to a number of serious diseases such as type 2 diabetes, cardiovascular disease, hypertension, stroke and cancer as well as psychological problems and a poor quality of life. High-fat diet-induced obesity in animal models Niloofar Hariri and Louise Thibault* School of Dietetics and Human Nutrition, McGill University, Quebec, Canada Epidemiological studies have shown a positive relationship between dietary fat intake and obesity.
Since rats and mice show a similar relationship, they are considered an appropriate modelCited by: Purchase Obesity - 1st Edition. Print Book & E-Book. ISBNObesity is a major public health concern because it predisposes the individual to many disorders, such as noninsulin-dependent diabetes, hypertension, stroke, and coronary artery disease, and has been associated with an increased incidence of certain cancers, notably cancers of the colon, rectum, prostate, breast, uterus, and cervix.
In. Obesity is an epidemic problem in the world and is associated with several health problems, including diabetes, cardiovascular disease, respiratory failure, muscle weakness, and cancer. The precise molecular mechanisms by which obesity induces these health problems are not yet clear.
To better understand the pathomechanisms of human disease, good animal models are by: Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public-health concern. Animal models Cited by: The most widely used obese animal models result from either genetic defects or consumption of high-fat diets.
Genetically obese animals used in cancer research include yellow obese mice, leptin and leptin receptor-deficient mice, and the Zucker rat. Goldthioglucose-induced obesity has occasionally been used as has been ovariectomized by: 2.